When a writing assignment lands journalist Raoul Duke and sidekick Dr. Gonzo in Las Vegas, they decide to make it the ultimate business trip. But before long, business has been forgotten and trip has become the key word. Fueled by a suitcase full of mind-bending pharmaceuticals, Duke and Gonzo set off on a fast and furious ride through nonstop neon, surreal surroundings and a crew of the craziest characters ever. But no matter where misadventure leads them, Duke and Gonzo discover that sometimes going too far is the only way to go. Featuring appearances by Harry Dean Stanton, Christina Ricci, Katherine Helmond, Penn Jillette and Lyle Lovett. Based on the classic 1971 novel by Hunter S. Thompson.